3EID

CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor

3EID の概要

• エントリーDOI: 10.2210/pdb3eid/pdb
• 分子名称: Cell division protein kinase 2, Cyclin-A2, (2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol, ... (4 entities in total)
• 機能のキーワード: cdk2, cyclin, atp-binding, cell cycle, cell division, kinase, mitosis, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, nucleus, transferase-cell cycle complex, transferase/cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128178.56

構造登録者

Steven, K.,Reno, M.,Alberti, J.,Price, D.,Kane-Carson, L.,Knick, V.,Shewchuk, L.,Hassell, A.,Veal, J.,Peel, M. (登録日: 2008-09-15, 公開日: 2008-10-21, 最終更新日: 2023-08-30)

• 主引用文献: Stevens, K.L.,Reno, M.J.,Alberti, J.B.,Price, D.J.,Kane-Carson, L.S.,Knick, V.B.,Shewchuk, L.M.,Hassell, A.M.,Veal, J.M.,Davis, S.T.,Griffin, R.J.,Peel, M.R.; Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.; Bioorg.Med.Chem.Lett., 18:5758-5762, 2008; PubMed: 18835709; DOI: 10.1016/j.bmcl.2008.09.069

実験手法

X-RAY DIFFRACTION (3.15 Å)