3EHX
Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor (R)-2-(biphenyl-4-ylsulfonamido)-4-methylpentanoic acid
Summary for 3EHX
| Entry DOI | 10.2210/pdb3ehx/pdb |
| Related | 3EHY |
| Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | matrix metalloproteinase, mmp12, elastase, complex (elastase-inhibitor), metallo elastase, calcium, extracellular matrix, glycoprotein, hydrolase, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P39900 |
| Total number of polymer chains | 1 |
| Total formula weight | 18082.96 |
| Authors | Calderone, V. (deposition date: 2008-09-15, release date: 2009-05-19, Last modification date: 2023-11-01) |
| Primary citation | Dragoni, E.,Calderone, V.,Fragai, M.,Jaiswal, R.,Luchinat, C.,Nativi, C. Biotin-tagged probes for MMP expression and activation: design, synthesis, and binding properties Bioconjug.Chem., 20:719-727, 2009 Cited by PubMed: 19275207DOI: 10.1021/bc8003827 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
