3EHT

Crystal structure of the extracellular domain of human corticotropin releasing factor receptor type 1 (CRFR1) in complex with CRF

3EHT の概要

• エントリーDOI: 10.2210/pdb3eht/pdb
• 関連するPDBエントリー: 3EHS 3EHU
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: FUSION PROTEIN OF CRFR1 EXTRACELLULAR DOMAIN AND MBP, Corticoliberin, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
• 機能のキーワード: g protein-coupled receptor, corticotropin releasing factor, scr fold, mbp fusion, extracellular domain, sugar transport, transport, cell membrane, glycoprotein, membrane, phosphoprotein, receptor, transducer, transmembrane, amidation, cleavage on pair of basic residues, hormone, secreted, membrane protein
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54624.46

構造登録者

Pioszak, A.A.,Xu, H.E. (登録日: 2008-09-14, 公開日: 2008-09-30, 最終更新日: 2023-08-30)

• 主引用文献: Pioszak, A.A.,Parker, N.R.,Suino-Powell, K.,Xu, H.E.; Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1.; J.Biol.Chem., 283:32900-32912, 2008; PubMed: 18801728; DOI: 10.1074/jbc.M805749200

実験手法

X-RAY DIFFRACTION (3.4 Å)