3EGK

KNOBLE Inhibitor

3EGK の概要

• エントリーDOI: 10.2210/pdb3egk/pdb
• 関連するPDBエントリー: 1H8D 1K22 1YPG 2ZDA 2ZGX 2ZHQ
• 分子名称: Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total)
• 機能のキーワード: blood clotting/hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35754.08

構造登録者

Baum, B.,Heine, A.,Klebe, G.,Muenzel, M. (登録日: 2008-09-10, 公開日: 2008-09-30, 最終更新日: 2023-11-15)

• 主引用文献: Gerlach, C.,Munzel, M.,Baum, B.,Gerber, H.-D.,Craan, T.,Diederich, W.E.,Klebe, G.; KNOBLE: a knowledge-based approach for the design and synthesis of readily accessible small-molecule chemical probes to test protein binding; Angew.Chem.Int.Ed.Engl., 46:9105-9109, 2007; PubMed: 17955562; DOI: 10.1002/anie.200703323

実験手法

X-RAY DIFFRACTION (2.2 Å)