3EG1

Crystal structure of the N114Q mutant of ABL-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

3EG1 の概要

• エントリーDOI: 10.2210/pdb3eg1/pdb
• 関連するPDBエントリー: 1BBZ 2O88 3EG0 3EG2 3EG3
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, p41 peptide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta, sh3 domain, atp-binding, cell adhesion, cytoskeleton, kinase, lipoprotein, magnesium, manganese, metal-binding, myristate, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase, signaling protein, transferase-signaling protein complex, transferase/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 16309.86

構造登録者

Camara-Artigas, A. (登録日: 2008-09-10, 公開日: 2009-09-15, 最終更新日: 2023-08-30)

• 主引用文献: Palencia, A.,Camara-Artigas, A.,Pisabarro, M.T.,Martinez, J.C.,Luque, I.; Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.; J.Biol.Chem., 285:2823-2833, 2010; PubMed: 19906645; DOI: 10.1074/jbc.M109.048033

実験手法

X-RAY DIFFRACTION (1.85 Å)