3EFK

Structure of c-Met with pyrimidone inhibitor 50

3EFK の概要

• エントリーDOI: 10.2210/pdb3efk/pdb
• 関連するPDBエントリー: 3efj
• 分子名称: Hepatocyte growth factor receptor, 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one (3 entities in total)
• 機能のキーワード: c-met, kinase inhibitor pyrimidone, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P08581
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71726.81

構造登録者

Bellon, S.F.,D'Angelo, N.,Whittington, D.,Dussault, I. (登録日: 2008-09-09, 公開日: 2008-10-07, 最終更新日: 2023-08-30)

• 主引用文献: D'Angelo, N.D.,Bellon, S.F.,Booker, S.K.,Cheng, Y.,Coxon, A.,Dominguez, C.,Fellows, I.,Hoffman, D.,Hungate, R.,Kaplan-Lefko, P.,Lee, M.R.,Li, C.,Liu, L.,Rainbeau, E.,Reider, P.J.,Rex, K.,Siegmund, A.,Sun, Y.,Tasker, A.S.,Xi, N.,Xu, S.,Yang, Y.,Zhang, Y.,Burgess, T.L.,Dussault, I.,Kim, T.S.; Design, synthesis, and biological evaluation of potent c-Met inhibitors.; J.Med.Chem., 51:5766-5779, 2008; PubMed: 18763753; DOI: 10.1021/jm8006189

実験手法

X-RAY DIFFRACTION (2.2 Å)