3EFK
Structure of c-Met with pyrimidone inhibitor 50
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hepatocyte growth factor receptor | polymer | 310 | 35346.9 | 2 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | C, D (A, B) | 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one | non-polymer | 516.5 | 2 | Chemie (MT4) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, B: 1048 - 1351 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1047 | - | initiating methionine |
| Leu 1272 | Val 1272 | engineered mutation |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
| His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70693.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1033.0 | |
| All* | Total formula weight | 71726.8 |
