3EFJ

Structure of c-Met with pyrimidone inhibitor 7

Summary for 3EFJ

Entry DOI	10.2210/pdb3efj/pdb
Related	3EFK
Descriptor	Hepatocyte growth factor receptor, 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one (3 entities in total)
Functional Keywords	c-met, alternative splicing, atp-binding, chromosomal rearrangement, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P08581
Total number of polymer chains	2
Total formula weight	71688.85
Authors	D'Angelo, N.,Bellon, S.,Whittington, D. (deposition date: 2008-09-09, release date: 2008-10-07, Last modification date: 2023-08-30)
Primary citation	D'Angelo, N.D.,Bellon, S.F.,Booker, S.K.,Cheng, Y.,Coxon, A.,Dominguez, C.,Fellows, I.,Hoffman, D.,Hungate, R.,Kaplan-Lefko, P.,Lee, M.R.,Li, C.,Liu, L.,Rainbeau, E.,Reider, P.J.,Rex, K.,Siegmund, A.,Sun, Y.,Tasker, A.S.,Xi, N.,Xu, S.,Yang, Y.,Zhang, Y.,Burgess, T.L.,Dussault, I.,Kim, T.S. Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51:5766-5779, 2008 Cited by PubMed: 18763753 DOI: 10.1021/jm8006189 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation