3EEL
Candida glabrata Dihydrofolate Reductase complexed with 2,4-diamino-5-[3-methyl-3-(3-methoxy-5-(3,5-dimethylphenyl)phenyl)prop-1-ynyl]-6-methylpyrimidine(UCP11153TM) and NADPH
Summary for 3EEL
| Entry DOI | 10.2210/pdb3eel/pdb |
| Related | 3EEJ 3EEK 3EEM |
| Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, ... (4 entities in total) |
| Functional Keywords | enzyme, oxidoreductase |
| Biological source | Candida glabrata (yeast) |
| Total number of polymer chains | 2 |
| Total formula weight | 55118.49 |
| Authors | Liu, J.,Anderson, A. (deposition date: 2008-09-04, release date: 2009-08-18, Last modification date: 2024-02-21) |
| Primary citation | Liu, J.,Bolstad, D.B.,Smith, A.E.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors Chem.Biol.Drug Des., 73:62-74, 2009 Cited by PubMed: 19152636DOI: 10.1111/j.1747-0285.2008.00745.x PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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