3EDZ
Crystal structure of catalytic domain of TACE with hydroxamate inhibitor
Summary for 3EDZ
Entry DOI | 10.2210/pdb3edz/pdb |
Related | 1BKC 2fv5 2fv9 |
Related PRD ID | PRD_000919 |
Descriptor | ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (6 entities in total) |
Functional Keywords | hydrolase, zn-endopeptidase, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 62687.58 |
Authors | Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X. (deposition date: 2008-09-03, release date: 2008-09-23, Last modification date: 2021-10-20) |
Primary citation | Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18:5809-5814, 2008 Cited by PubMed: 18835710DOI: 10.1016/j.bmcl.2008.09.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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