3EDZ

Crystal structure of catalytic domain of TACE with hydroxamate inhibitor

3EDZ の概要

• エントリーDOI: 10.2210/pdb3edz/pdb
• 関連するPDBエントリー: 1BKC 2fv5 2fv9
• 関連するBIRD辞書のPRD_ID: PRD_000919
• 分子名称: ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (6 entities in total)
• 機能のキーワード: hydrolase, zn-endopeptidase, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62687.58

構造登録者

Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X. (登録日: 2008-09-03, 公開日: 2008-09-23, 最終更新日: 2021-10-20)

• 主引用文献: Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X.; Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.; Bioorg.Med.Chem.Lett., 18:5809-5814, 2008; PubMed: 18835710; DOI: 10.1016/j.bmcl.2008.09.045

実験手法

X-RAY DIFFRACTION (1.9 Å)