3EDY
Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1
Summary for 3EDY
Entry DOI | 10.2210/pdb3edy/pdb |
Descriptor | Tripeptidyl-peptidase 1, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | protease, tpp1, sedolisin, batten disease, lincl, zymogen, prodomain, exopeptidase, endopeptidase, s53 family, cln2, catalytic triad, oxyanion hole, disease mutation, epilepsy, glycoprotein, hydrolase, lysosome, neuronal ceroid lipofuscinosis, serine protease |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome : O14773 |
Total number of polymer chains | 1 |
Total formula weight | 60542.30 |
Authors | Guhaniyogi, J.,Sohar, I.,Das, K.,Lobel, P.,Stock, A.M. (deposition date: 2008-09-03, release date: 2008-11-18, Last modification date: 2020-07-29) |
Primary citation | Guhaniyogi, J.,Sohar, I.,Das, K.,Stock, A.M.,Lobel, P. Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis J.Biol.Chem., 284:3985-3997, 2009 Cited by PubMed: 19038967DOI: 10.1074/jbc.M806943200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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