3EDY

Crystal Structure of the Precursor Form of Human Tripeptidyl-Peptidase 1

3EDY の概要

• エントリーDOI: 10.2210/pdb3edy/pdb
• 分子名称: Tripeptidyl-peptidase 1, CALCIUM ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: protease, tpp1, sedolisin, batten disease, lincl, zymogen, prodomain, exopeptidase, endopeptidase, s53 family, cln2, catalytic triad, oxyanion hole, disease mutation, epilepsy, glycoprotein, hydrolase, lysosome, neuronal ceroid lipofuscinosis, serine protease
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome : O14773
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60542.30

構造登録者

Guhaniyogi, J.,Sohar, I.,Das, K.,Lobel, P.,Stock, A.M. (登録日: 2008-09-03, 公開日: 2008-11-18, 最終更新日: 2020-07-29)

• 主引用文献: Guhaniyogi, J.,Sohar, I.,Das, K.,Stock, A.M.,Lobel, P.; Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis; J.Biol.Chem., 284:3985-3997, 2009; PubMed: 19038967; DOI: 10.1074/jbc.M806943200

実験手法

X-RAY DIFFRACTION (1.85 Å)