3EBO

Glycogen Phosphorylase b/Chrysin complex

3EBO の概要

• エントリーDOI: 10.2210/pdb3ebo/pdb
• 関連するPDBエントリー: 1c8k 1e1y 3EBP
• 分子名称: Glycogen phosphorylase, muscle form, chrysin (3 entities in total)
• 機能のキーワード: glycogen phosphorylase, catalytic site, rational inhibitor design, glycogenolysis, diabetes type 2, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97773.56

構造登録者

Oikonomakos, N.G.,Zographos, S.E.,Leonidas, D.D.,Hayes, J.M.,Tiraidis, C.,Alexacou, K.-M. (登録日: 2008-08-28, 公開日: 2009-09-01, 最終更新日: 2023-11-15)

• 主引用文献: Tsitsanou, K.E.,Hayes, J.M.,Keramioti, M.,Mamais, M.,Oikonomakos, N.G.,Kato, A.,Leonidas, D.D.,Zographos, S.E.; Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol; Food Chem.Toxicol., 61:14-27, 2013; PubMed: 23279842; DOI: 10.1016/j.fct.2012.12.030

実験手法

X-RAY DIFFRACTION (1.9 Å)