3EBA

CAbHul6 FGLW mutant (humanized) in complex with human lysozyme

3EBA の概要

• エントリーDOI: 10.2210/pdb3eba/pdb
• 関連するPDBエントリー: 1op9
• 分子名称: CAbHul6, Lysozyme C, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: antigen-antibody complex, immunoglobulin, nanobody, humanization, amyloid fibril formation inhibition, amyloid, antimicrobial, bacteriolytic enzyme, disease mutation, glycosidase, hydrolase, polymorphism, immune system-hydrolase complex, immune system/hydrolase
• 由来する生物種: Camelus dromedarius; 詳細
• 細胞内の位置: Secreted: P61626
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29148.28

構造登録者

Loris, R.,Vincke, C.,Saerens, D.,Martinez-Rodriguez, S.,Muyldermans, S.,Conrath, K. (登録日: 2008-08-27, 公開日: 2008-12-02, 最終更新日: 2023-11-01)

• 主引用文献: Vincke, C.,Loris, R.,Saerens, D.,Martinez-Rodriguez, S.,Muyldermans, S.,Conrath, K.; General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold; J.Biol.Chem., 284:3273-3284, 2009; PubMed: 19010777; DOI: 10.1074/jbc.M806889200

実験手法

X-RAY DIFFRACTION (1.85 Å)