3E90
West Nile vi rus NS2B-NS3protease in complexed with inhibitor Naph-KKR-H
Summary for 3E90
Entry DOI | 10.2210/pdb3e90/pdb |
Descriptor | NS2B cofactor, NS3 protease, N~2~-(naphthalen-2-ylcarbonyl)-L-lysyl-N-[(1S)-4-carbamimidamido-1-formylbutyl]-L-lysinamide, ... (4 entities in total) |
Functional Keywords | west nile virus, ns3 protease, trypsin-like serine protease, protease inhibitor, catalytic histidine, induced fit, atp-binding, capsid protein, helicase, hydrolase, nucleotide-binding, rna replication, transmembrane, virion |
Biological source | West Nile virus (WNV) More |
Total number of polymer chains | 4 |
Total formula weight | 54633.15 |
Authors | Martin, J.L.,Robin, G. (deposition date: 2008-08-21, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Robin, G.,Chappell, K.,Stoermer, M.J.,Hu, S.-H.,Young, P.R.,Fairlie, D.P.,Martin, J.L. Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation J.Mol.Biol., 385:1568-1577, 2009 Cited by PubMed: 19059417DOI: 10.1016/j.jmb.2008.11.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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