3E90

West Nile vi rus NS2B-NS3protease in complexed with inhibitor Naph-KKR-H

3E90 の概要

• エントリーDOI: 10.2210/pdb3e90/pdb
• 分子名称: NS2B cofactor, NS3 protease, N~2~-(naphthalen-2-ylcarbonyl)-L-lysyl-N-[(1S)-4-carbamimidamido-1-formylbutyl]-L-lysinamide, ... (4 entities in total)
• 機能のキーワード: west nile virus, ns3 protease, trypsin-like serine protease, protease inhibitor, catalytic histidine, induced fit, atp-binding, capsid protein, helicase, hydrolase, nucleotide-binding, rna replication, transmembrane, virion
• 由来する生物種: West Nile virus (WNV); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 54633.15

構造登録者

Martin, J.L.,Robin, G. (登録日: 2008-08-21, 公開日: 2009-01-20, 最終更新日: 2023-11-01)

• 主引用文献: Robin, G.,Chappell, K.,Stoermer, M.J.,Hu, S.-H.,Young, P.R.,Fairlie, D.P.,Martin, J.L.; Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation; J.Mol.Biol., 385:1568-1577, 2009; PubMed: 19059417; DOI: 10.1016/j.jmb.2008.11.026

実験手法

X-RAY DIFFRACTION (2.45 Å)