3E7V
Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand
Summary for 3E7V
Entry DOI | 10.2210/pdb3e7v/pdb |
Descriptor | Serine/threonine-protein kinase haspin, 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine, NICKEL (II) ION, ... (5 entities in total) |
Functional Keywords | haspin, germ cell associated 2 (haspin), haploid germ cell specific nuclear protein kinase, sgc, structural genomics consortium, atp-binding, cell cycle, chromatin regulator, kinase, magnesium, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q8TF76 |
Total number of polymer chains | 1 |
Total formula weight | 41540.44 |
Authors | Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wickstroem, M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-08-19, release date: 2008-10-14, Last modification date: 2023-08-30) |
Primary citation | Filippakopoulos, P.,Eswaran, J.,Keates, T.,Burgess-Brown, N.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wickstroem, M.,Bountra, C.,Knapp, S. Crystal Structure of Human Haspin with a pyrazolo-pyrimidine ligand To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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