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3E68

Structure of murine INOS oxygenase domain with inhibitor AR-C130232

Summary for 3E68
Entry DOI10.2210/pdb3e68/pdb
Related3E65 3E67
DescriptorNitric oxide synthase, inducible, octyl beta-D-glucopyranoside, SULFATE ION, ... (8 entities in total)
Functional Keywordsnitric oxide, nos, heme, tetrahydrobiopterin, oxidoreductase, calmodulin-binding, fad, fmn, iron, metal-binding, nadp, polymorphism, zinc
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total formula weight103955.48
Authors
Primary citationGarcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D.
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4:700-707, 2008
Cited by
PubMed: 18849972
DOI: 10.1038/nchembio.115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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