3E50
Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha
Summary for 3E50
Entry DOI | 10.2210/pdb3e50/pdb |
Related | 3E4Z |
Descriptor | Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION, ... (4 entities in total) |
Functional Keywords | ide, tgf-alpha, cytoplasm, hydrolase, metal-binding, metalloprotease, polymorphism, protease, zinc, cell membrane, egf-like domain, glycoprotein, growth factor, lipoprotein, membrane, mitogen, palmitate, secreted, transmembrane, hydrolase-hormone complex, hydrolase/hormone |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm: P14735 Transforming growth factor alpha: Secreted, extracellular space. Protransforming growth factor alpha: Cell membrane; Single-pass type I membrane protein: P01135 |
Total number of polymer chains | 4 |
Total formula weight | 240681.59 |
Authors | Guo, Q.,Manolopoulou, M.,Tang, W.-J. (deposition date: 2008-08-12, release date: 2009-08-18, Last modification date: 2024-02-21) |
Primary citation | Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J. Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395:430-443, 2010 Cited by PubMed: 19896952DOI: 10.1016/j.jmb.2009.10.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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