3E4Z
Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II
Summary for 3E4Z
Entry DOI | 10.2210/pdb3e4z/pdb |
Related | 3E50 |
Descriptor | Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION, ... (4 entities in total) |
Functional Keywords | ide, igf-ii, degrading, complex, alternative splicing, glycoprotein, growth factor, mitogen, polymorphism, secreted, hydrolase-hormone complex, hydrolase/hormone |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01344 |
Total number of polymer chains | 4 |
Total formula weight | 244217.07 |
Authors | Guo, Q.,Manolopoulou, M.,Tang, W.-J. (deposition date: 2008-08-12, release date: 2009-08-18, Last modification date: 2024-02-21) |
Primary citation | Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J. Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395:430-443, 2010 Cited by PubMed: 19896952DOI: 10.1016/j.jmb.2009.10.072 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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