3E4Z

Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II

Summary for 3E4Z

• Entry DOI: 10.2210/pdb3e4z/pdb
• Related: 3E50
• Descriptor: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION, ... (4 entities in total)
• Functional Keywords: ide, igf-ii, degrading, complex, alternative splicing, glycoprotein, growth factor, mitogen, polymorphism, secreted, hydrolase-hormone complex, hydrolase/hormone
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01344
• Total number of polymer chains: 4
• Total formula weight: 244217.07

Authors

Guo, Q.,Manolopoulou, M.,Tang, W.-J. (deposition date: 2008-08-12, release date: 2009-08-18, Last modification date: 2024-02-21)

• Primary citation: Guo, Q.,Manolopoulou, M.,Bian, Y.,Schilling, A.B.,Tang, W.J.; Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme.; J.Mol.Biol., 395:430-443, 2010; PubMed: 19896952; DOI: 10.1016/j.jmb.2009.10.072

Experimental method

X-RAY DIFFRACTION (2.28 Å)