3E4E

Human cytochrome P450 2E1 in complex with the inhibitor 4-methylpyrazole

Summary for 3E4E

Entry DOI	10.2210/pdb3e4e/pdb
Descriptor	Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, 4-methyl-1H-pyrazole, ... (4 entities in total)
Functional Keywords	cyp2e1, p450 2e1, monooxygenase, acetaminophen, oxidoreductase, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Peripheral membrane protein: P05181
Total number of polymer chains	2
Total formula weight	111514.16
Authors	Meneely, K.M.,Porubsky, P.R.,Scott, E.E. (deposition date: 2008-08-11, release date: 2008-09-16, Last modification date: 2023-08-30)
Primary citation	Porubsky, P.R.,Meneely, K.M.,Scott, E.E. Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J.Biol.Chem., 283:33698-33707, 2008 Cited by PubMed: 18818195 DOI: 10.1074/jbc.M805999200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation