3E4E
Human cytochrome P450 2E1 in complex with the inhibitor 4-methylpyrazole
Summary for 3E4E
Entry DOI | 10.2210/pdb3e4e/pdb |
Descriptor | Cytochrome P450 2E1, PROTOPORPHYRIN IX CONTAINING FE, 4-methyl-1H-pyrazole, ... (4 entities in total) |
Functional Keywords | cyp2e1, p450 2e1, monooxygenase, acetaminophen, oxidoreductase, heme, endoplasmic reticulum, iron, membrane, metal-binding, microsome |
Biological source | Homo sapiens (Human) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P05181 |
Total number of polymer chains | 2 |
Total formula weight | 111514.16 |
Authors | Meneely, K.M.,Porubsky, P.R.,Scott, E.E. (deposition date: 2008-08-11, release date: 2008-09-16, Last modification date: 2023-08-30) |
Primary citation | Porubsky, P.R.,Meneely, K.M.,Scott, E.E. Structures of human cytochrome P450 2E1: insights into the binding of inhibitors and both small molecular weight and fatty acid substrates. J.Biol.Chem., 283:33698-33707, 2008 Cited by PubMed: 18818195DOI: 10.1074/jbc.M805999200 PDB entries with the same primary citation |
Experimental method |
Structure validation
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