3E4A
Human IDE-inhibitor complex at 2.6 angstrom resolution
Summary for 3E4A
Entry DOI | 10.2210/pdb3e4a/pdb |
Descriptor | Insulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ... (7 entities in total) |
Functional Keywords | insulin, hydroxamate, insulin degrading enzyme, hydrolase, metal-binding, metalloprotease, protease |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 4 |
Total formula weight | 239073.28 |
Authors | Malito, E.,Leissring, M.A.,Choi, S.,Cuny, G.D.,Tang, W.J. (deposition date: 2008-08-11, release date: 2009-05-19, Last modification date: 2023-08-30) |
Primary citation | Leissring, M.A.,Malito, E.,Hedouin, S.,Reinstatler, L.,Sahara, T.,Abdul-Hay, S.O.,Choudhry, S.,Maharvi, G.M.,Fauq, A.H.,Huzarska, M.,May, P.S.,Choi, S.,Logan, T.P.,Turk, B.E.,Cantley, L.C.,Manolopoulou, M.,Tang, W.J.,Stein, R.L.,Cuny, G.D.,Selkoe, D.J. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One, 5:e10504-e10504, 2010 Cited by PubMed: 20498699DOI: 10.1371/journal.pone.0010504 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report