3E4A
Human IDE-inhibitor complex at 2.6 angstrom resolution
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001618 | molecular_function | virus receptor activity |
A | 0004175 | molecular_function | endopeptidase activity |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005777 | cellular_component | peroxisome |
A | 0005782 | cellular_component | peroxisomal matrix |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0008286 | biological_process | insulin receptor signaling pathway |
A | 0009897 | cellular_component | external side of plasma membrane |
A | 0009986 | cellular_component | cell surface |
A | 0010815 | biological_process | bradykinin catabolic process |
A | 0010992 | biological_process | ubiquitin recycling |
A | 0016323 | cellular_component | basolateral plasma membrane |
A | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
A | 0030163 | biological_process | protein catabolic process |
A | 0032092 | biological_process | positive regulation of protein binding |
A | 0042277 | molecular_function | peptide binding |
A | 0042447 | biological_process | hormone catabolic process |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0043171 | biological_process | peptide catabolic process |
A | 0043559 | molecular_function | insulin binding |
A | 0045732 | biological_process | positive regulation of protein catabolic process |
A | 0046718 | biological_process | symbiont entry into host cell |
A | 0046872 | molecular_function | metal ion binding |
A | 0050435 | biological_process | amyloid-beta metabolic process |
A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
A | 0070062 | cellular_component | extracellular exosome |
A | 0097242 | biological_process | amyloid-beta clearance |
A | 0150094 | biological_process | amyloid-beta clearance by cellular catabolic process |
A | 1901142 | biological_process | insulin metabolic process |
A | 1901143 | biological_process | insulin catabolic process |
A | 1903715 | biological_process | regulation of aerobic respiration |
B | 0001618 | molecular_function | virus receptor activity |
B | 0004175 | molecular_function | endopeptidase activity |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005777 | cellular_component | peroxisome |
B | 0005782 | cellular_component | peroxisomal matrix |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0008286 | biological_process | insulin receptor signaling pathway |
B | 0009897 | cellular_component | external side of plasma membrane |
B | 0009986 | cellular_component | cell surface |
B | 0010815 | biological_process | bradykinin catabolic process |
B | 0010992 | biological_process | ubiquitin recycling |
B | 0016323 | cellular_component | basolateral plasma membrane |
B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
B | 0030163 | biological_process | protein catabolic process |
B | 0032092 | biological_process | positive regulation of protein binding |
B | 0042277 | molecular_function | peptide binding |
B | 0042447 | biological_process | hormone catabolic process |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0043171 | biological_process | peptide catabolic process |
B | 0043559 | molecular_function | insulin binding |
B | 0045732 | biological_process | positive regulation of protein catabolic process |
B | 0046718 | biological_process | symbiont entry into host cell |
B | 0046872 | molecular_function | metal ion binding |
B | 0050435 | biological_process | amyloid-beta metabolic process |
B | 0051603 | biological_process | proteolysis involved in protein catabolic process |
B | 0070062 | cellular_component | extracellular exosome |
B | 0097242 | biological_process | amyloid-beta clearance |
B | 0150094 | biological_process | amyloid-beta clearance by cellular catabolic process |
B | 1901142 | biological_process | insulin metabolic process |
B | 1901143 | biological_process | insulin catabolic process |
B | 1903715 | biological_process | regulation of aerobic respiration |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 2000 |
Chain | Residue |
A | HIS108 |
A | HIS112 |
A | GLU189 |
A | QIX2001 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE QIX A 2001 |
Chain | Residue |
A | ASN139 |
A | ALA140 |
A | GLU189 |
A | PHE820 |
A | ARG824 |
A | TYR831 |
A | ZN2000 |
A | HIS108 |
A | GLN111 |
A | HIS112 |
A | LEU116 |
A | SER128 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE DIO A 2002 |
Chain | Residue |
A | GLN800 |
A | GLU910 |
A | SER913 |
A | ARG920 |
A | DIO2003 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DIO A 2003 |
Chain | Residue |
A | GLN800 |
A | ARG839 |
A | ALA840 |
A | ASN841 |
A | GLY842 |
A | DIO2002 |
site_id | AC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACY A 2004 |
Chain | Residue |
A | LYS558 |
A | TYR916 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE ACY A 2005 |
Chain | Residue |
A | LYS120 |
site_id | AC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE ACY A 2006 |
Chain | Residue |
A | GLU290 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACY A 2007 |
Chain | Residue |
A | GLU465 |
A | PRO639 |
A | MET744 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACY A 2008 |
Chain | Residue |
A | GLU990 |
A | PHE998 |
A | GLY1001 |
A | LEU1002 |
site_id | BC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE ACY A 2009 |
Chain | Residue |
A | GLU529 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACY A 2010 |
Chain | Residue |
A | ASN312 |
A | THR358 |
A | VAL360 |
A | VAL377 |
A | ASP378 |
site_id | BC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE ACY A 2011 |
Chain | Residue |
A | LEU204 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2000 |
Chain | Residue |
B | HIS108 |
B | HIS112 |
B | GLU189 |
B | QIX2001 |
site_id | BC5 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE QIX B 2001 |
Chain | Residue |
B | HIS108 |
B | GLN111 |
B | HIS112 |
B | LEU116 |
B | SER128 |
B | ASN139 |
B | ALA140 |
B | GLU182 |
B | GLU189 |
B | PHE820 |
B | ARG824 |
B | TYR831 |
B | ZN2000 |
B | HOH2160 |
B | HOH2164 |
site_id | BC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE DIO B 2002 |
Chain | Residue |
B | LEU201 |
B | LEU204 |
B | GLU205 |
B | THR208 |
B | ARG477 |
B | ALA479 |
B | HOH2018 |
B | HOH2054 |
site_id | BC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DIO B 2003 |
Chain | Residue |
B | GLN800 |
B | ARG839 |
B | ALA840 |
B | ASN841 |
B | SER913 |
B | DIO2004 |
site_id | BC8 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DIO B 2004 |
Chain | Residue |
B | SER913 |
B | DIO2003 |
site_id | BC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DIO B 2005 |
Chain | Residue |
B | LEU170 |
B | HIS245 |
site_id | CC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE DIO B 2006 |
Chain | Residue |
B | ASP698 |
B | TYR779 |
site_id | CC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACY B 2007 |
Chain | Residue |
B | GLY775 |
B | TRP776 |
B | GLU990 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACY B 2008 |
Chain | Residue |
B | LYS212 |
B | HIS213 |
B | PRO214 |
B | GLU290 |
site_id | CC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE ACY B 2009 |
Chain | Residue |
B | GLU529 |
site_id | CC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACY B 2010 |
Chain | Residue |
B | THR358 |
B | VAL377 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACY B 2011 |
Chain | Residue |
A | LYS1009 |
B | GLU990 |
B | PHE998 |
B | GLY1001 |
site_id | CC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE ACY B 2012 |
Chain | Residue |
B | TRP513 |
B | LEU301 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000305|PubMed:10684867, ECO:0000305|PubMed:17051221, ECO:0000305|PubMed:19321446, ECO:0000305|PubMed:23922390 |
Chain | Residue | Details |
A | GLN111 | |
B | GLN111 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10096, ECO:0000269|PubMed:17051221, ECO:0000269|PubMed:17613531, ECO:0000269|PubMed:18986166, ECO:0000269|PubMed:19321446, ECO:0007744|PDB:2G54, ECO:0007744|PDB:2JG4, ECO:0007744|PDB:3CWW, ECO:0007744|PDB:3N56, ECO:0007744|PDB:3N57 |
Chain | Residue | Details |
A | HIS108 | |
A | HIS112 | |
A | GLU189 | |
B | HIS108 | |
B | HIS112 | |
B | GLU189 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: in the exosite |
Chain | Residue | Details |
A | HIS336 | |
B | HIS336 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18986166 |
Chain | Residue | Details |
A | LEU359 | |
B | LEU359 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P35559 |
Chain | Residue | Details |
A | ARG429 | |
A | ASP895 | |
B | ARG429 | |
B | ASP895 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9JHR7 |
Chain | Residue | Details |
A | LYS192 | |
A | LYS697 | |
B | LYS192 | |
B | LYS697 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hr6 |
Chain | Residue | Details |
A | GLN111 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hr6 |
Chain | Residue | Details |
B | GLN111 |