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3E4A

Human IDE-inhibitor complex at 2.6 angstrom resolution

Summary for 3E4A
Entry DOI10.2210/pdb3e4a/pdb
DescriptorInsulin-degrading enzyme, HYDROXAMATE PEPTIDE II1, ZINC ION, ... (7 entities in total)
Functional Keywordsinsulin, hydroxamate, insulin degrading enzyme, hydrolase, metal-binding, metalloprotease, protease
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P14735
Total number of polymer chains4
Total formula weight239073.28
Authors
Malito, E.,Leissring, M.A.,Choi, S.,Cuny, G.D.,Tang, W.J. (deposition date: 2008-08-11, release date: 2009-05-19, Last modification date: 2023-08-30)
Primary citationLeissring, M.A.,Malito, E.,Hedouin, S.,Reinstatler, L.,Sahara, T.,Abdul-Hay, S.O.,Choudhry, S.,Maharvi, G.M.,Fauq, A.H.,Huzarska, M.,May, P.S.,Choi, S.,Logan, T.P.,Turk, B.E.,Cantley, L.C.,Manolopoulou, M.,Tang, W.J.,Stein, R.L.,Cuny, G.D.,Selkoe, D.J.
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Plos One, 5:e10504-e10504, 2010
Cited by
PubMed: 20498699
DOI: 10.1371/journal.pone.0010504
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

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