3DYG
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
Summary for 3DYG
Entry DOI | 10.2210/pdb3dyg/pdb |
Related | 2EWG 2I19 2OGD 3DYF 3DYH |
Descriptor | FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, ACETATE ION, ... (7 entities in total) |
Functional Keywords | protein-bisphosphonate complex, isoprene biosynthesis, transferase |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 90212.23 |
Authors | Cao, R.,Gao, Y.,Robinson, H.,Goddard, A.,Oldfield, E. (deposition date: 2008-07-27, release date: 2009-05-05, Last modification date: 2023-08-30) |
Primary citation | Zhang, Y.,Cao, R.,Yin, F.,Hudock, M.P.,Guo, R.T.,Krysiak, K.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Bergan, K.,Leon, A.,Cass, L.,Goddard, A.,Chang, T.K.,Lin, F.Y.,Van Beek, E.,Papapoulos, S.,Wang, A.H.,Kubo, T.,Ochi, M.,Mukkamala, D.,Oldfield, E. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. J.Am.Chem.Soc., 131:5153-5162, 2009 Cited by PubMed: 19309137DOI: 10.1021/ja808285e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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