3DYG
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 3002 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | HOH5003 |
| A | HOH5516 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3003 |
| Chain | Residue |
| A | ASP255 |
| A | LYS269 |
| A | HOH5001 |
| A | HOH5002 |
| A | HOH5012 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 3004 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | HOH5005 |
| A | HOH5006 |
| A | HOH5014 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4002 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | HOH5004 |
| B | HOH5082 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 4003 |
| Chain | Residue |
| B | ASP255 |
| B | HOH5010 |
| B | HOH5015 |
| B | HOH5298 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 4004 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | HOH5007 |
| B | HOH5008 |
| B | HOH5009 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 8001 |
| Chain | Residue |
| A | GLY46 |
| A | LYS47 |
| A | GLN96 |
| A | ARG113 |
| A | LYS367 |
| A | HOH5016 |
| A | HOH5035 |
| A | HOH5477 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 8002 |
| Chain | Residue |
| B | LYS47 |
| B | ARG50 |
| B | GLN96 |
| B | ARG113 |
| B | HOH5063 |
| B | HOH5176 |
| B | HOH5201 |
| B | HOH5341 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NI9 A 3001 |
| Chain | Residue |
| A | TYR99 |
| A | ASP103 |
| A | ASP107 |
| A | ARG112 |
| A | GLN172 |
| A | LYS212 |
| A | THR213 |
| A | ASP255 |
| A | LYS269 |
| A | HOH5001 |
| A | HOH5006 |
| A | HOH5014 |
| A | HOH5081 |
| A | HOH5113 |
| A | HOH5252 |
| A | HOH5516 |
| A | HOH5551 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NI9 B 4001 |
| Chain | Residue |
| B | TYR99 |
| B | ASP103 |
| B | ASP107 |
| B | ARG112 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | ASP255 |
| B | LYS269 |
| B | HOH5008 |
| B | HOH5009 |
| B | HOH5013 |
| B | HOH5015 |
| B | HOH5082 |
| B | HOH5184 |
| B | HOH5185 |
| B | HOH5298 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A 9001 |
| Chain | Residue |
| A | ASP156 |
| A | CYS159 |
| A | ARG160 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME B 9002 |
| Chain | Residue |
| B | CYS159 |
| B | ARG160 |
| B | ARG163 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 7001 |
| Chain | Residue |
| A | ARG163 |
| A | TYR215 |
| A | GLU241 |
| A | HOH5023 |
| A | HOH5440 |
| B | LYS24 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 7002 |
| Chain | Residue |
| A | LYS24 |
| A | PHE25 |
| B | ARG163 |
| B | THR167 |
| B | TYR215 |
Functional Information from PROSITE/UniProt
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | PHE251 | |
| A | ARG112 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | PHE251 | |
| B | ARG112 |
