3DY6

PPARdelta complexed with an anthranilic acid partial agonist

3DY6 の概要

• エントリーDOI: 10.2210/pdb3dy6/pdb
• 関連するPDBエントリー: 1gwx
• 分子名称: Peroxisome proliferator-activated receptor delta, IODIDE ION, 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid, ... (4 entities in total)
• 機能のキーワード: ppar, nulear receptor, activator, dna-binding, metal-binding, nucleus, transcription, transcription regulation, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q03181
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63033.99

構造登録者

Lambert, M.L.,Xu, R.,Shearer, B.G.,Wilson, T.M. (登録日: 2008-07-25, 公開日: 2008-10-07, 最終更新日: 2023-08-30)

主引用文献

Shearer, B.G.,Patel, H.S.,Billin, A.N.,Way, J.M.,Winegar, D.A.,Lambert, M.H.,Xu, R.X.,Leesnitzer, L.M.,Merrihew, R.V.,Huet, S.,Willson, T.M.
Discovery of a novel class of PPARdelta partial agonists
Bioorg.Med.Chem.Lett., 18:5018-5022, 2008

PubMed Abstract: Anthranilic acid GW9371 was identified as a novel class of PPARdelta partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells.

PubMed: 18722772
DOI: 10.1016/j.bmcl.2008.08.011

実験手法

X-RAY DIFFRACTION (2.9 Å)