3DXJ
Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin
Summary for 3DXJ
Entry DOI | 10.2210/pdb3dxj/pdb |
Related | 1IW7 1ZYR |
Descriptor | DNA-directed RNA polymerase subunit alpha; CHAIN A, B, K, L, methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... (11 entities in total) |
Functional Keywords | rna polymerase; rnap; drug complex; inhibitor; corallopyronin; ripostatin; transcription; holoenzyme; crystallography; twinning; hemihedral, dna-directed rna polymerase, nucleotidyltransferase, transcription, transferase, dna-binding, sigma factor, transcription regulation |
Biological source | Thermus thermophilus HB8 More |
Total number of polymer chains | 12 |
Total formula weight | 855045.03 |
Authors | Das, K.,Arnold, E. (deposition date: 2008-07-24, release date: 2008-10-14, Last modification date: 2023-08-30) |
Primary citation | Mukhopadhyay, J.,Das, K.,Ismail, S.,Koppstein, D.,Jang, M.,Hudson, B.,Sarafianos, S.,Tuske, S.,Patel, J.,Jansen, R.,Irschik, H.,Arnold, E.,Ebright, R.H. The RNA polymerase "switch region" is a target for inhibitors. Cell(Cambridge,Mass.), 135:295-307, 2008 Cited by PubMed: 18957204DOI: 10.1016/j.cell.2008.09.033 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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