3DXJ

Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin

3DXJ の概要

• エントリーDOI: 10.2210/pdb3dxj/pdb
• 関連するPDBエントリー: 1IW7 1ZYR
• 分子名称: DNA-directed RNA polymerase subunit alpha; CHAIN A, B, K, L, methyl [(1E,5R)-5-{(3S)-3-[(2E,4E)-2,5-dimethylocta-2,4-dienoyl]-2,4-dioxo-3,4-dihydro-2H-pyran-6-yl}hexylidene]carbamate, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ... (11 entities in total)
• 機能のキーワード: rna polymerase; rnap; drug complex; inhibitor; corallopyronin; ripostatin; transcription; holoenzyme; crystallography; twinning; hemihedral, dna-directed rna polymerase, nucleotidyltransferase, transcription, transferase, dna-binding, sigma factor, transcription regulation
• 由来する生物種: Thermus thermophilus HB8; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 855045.03

構造登録者

Das, K.,Arnold, E. (登録日: 2008-07-24, 公開日: 2008-10-14, 最終更新日: 2023-08-30)

• 主引用文献: Mukhopadhyay, J.,Das, K.,Ismail, S.,Koppstein, D.,Jang, M.,Hudson, B.,Sarafianos, S.,Tuske, S.,Patel, J.,Jansen, R.,Irschik, H.,Arnold, E.,Ebright, R.H.; The RNA polymerase "switch region" is a target for inhibitors.; Cell(Cambridge,Mass.), 135:295-307, 2008; PubMed: 18957204; DOI: 10.1016/j.cell.2008.09.033

実験手法

X-RAY DIFFRACTION (3 Å)