3DXE
Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2
3DXE の概要
エントリーDOI | 10.2210/pdb3dxe/pdb |
関連するPDBエントリー | 3DXC 3DXD |
分子名称 | Amyloid beta A4 protein-binding family B member 1, Amyloid beta A4 protein (3 entities in total) |
機能のキーワード | alzheimer's disease, app, aicd, fe65, ptb domain, alzheimer disease, amyloid, apoptosis, cell adhesion, coated pit, disease mutation, endocytosis, glycoprotein, heparin-binding, iron, membrane, metal-binding, notch signaling pathway, phosphoprotein, protease inhibitor, proteoglycan, serine protease inhibitor, transmembrane, protein binding |
由来する生物種 | Homo sapiens (Human) 詳細 |
細胞内の位置 | Cell membrane: O00213 Membrane; Single-pass type I membrane protein: P05067 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 39050.34 |
構造登録者 | |
主引用文献 | Radzimanowski, J.,Simon, B.,Sattler, M.,Beyreuther, K.,Sinning, I.,Wild, K. Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. Embo Rep., 9:1134-1140, 2008 Cited by PubMed: 18833287DOI: 10.1038/embor.2008.188 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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