3DXC
Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2
Summary for 3DXC
Entry DOI | 10.2210/pdb3dxc/pdb |
Related | 3DXD 3DXE |
Descriptor | Amyloid beta A4 protein-binding family B member 1, Amyloid beta A4 protein (3 entities in total) |
Functional Keywords | alzheimer's disease, app, aicd, fe65, ptb domain, alzheimer disease, amyloid, apoptosis, cell adhesion, coated pit, disease mutation, endocytosis, glycoprotein, heparin-binding, iron, membrane, metal-binding, notch signaling pathway, phosphoprotein, protease inhibitor, proteoglycan, serine protease inhibitor, transmembrane, protein binding |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane: O00213 Membrane; Single-pass type I membrane protein: P05067 |
Total number of polymer chains | 4 |
Total formula weight | 39110.39 |
Authors | Radzimanowski, J.,Sinning, I.,Wild, K. (deposition date: 2008-07-24, release date: 2008-09-16, Last modification date: 2024-02-21) |
Primary citation | Radzimanowski, J.,Simon, B.,Sattler, M.,Beyreuther, K.,Sinning, I.,Wild, K. Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2. Embo Rep., 9:1134-1140, 2008 Cited by PubMed: 18833287DOI: 10.1038/embor.2008.188 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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