3DWZ

Meropenem Covalent Adduct with TB Beta-lactamase

3DWZ の概要

• エントリーDOI: 10.2210/pdb3dwz/pdb
• 関連するPDBエントリー: 3cg5
• 分子名称: Beta-lactamase, PHOSPHATE ION, (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: alpha-beta folded protein, protein-covalent adduct, antibiotic resistance, hydrolase, lipoprotein, membrane, palmitate, meropenem (open form), hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28848.14

構造登録者

Tremblay, L.W.,Hugonnet, J.E.,Blanchard, J.S. (登録日: 2008-07-23, 公開日: 2009-03-10, 最終更新日: 2023-08-30)

• 主引用文献: Hugonnet, J.E.,Tremblay, L.W.,Boshoff, H.I.,Barry, C.E.,Blanchard, J.S.; Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis; Science, 323:1215-1218, 2009; PubMed: 19251630; DOI: 10.1126/science.1167498

実験手法

X-RAY DIFFRACTION (1.8 Å)