3DWY
Crystal Structure of the Bromodomain of Human CREBBP
Summary for 3DWY
Entry DOI | 10.2210/pdb3dwy/pdb |
Descriptor | CREB-binding protein, 1,2-ETHANEDIOL (3 entities in total) |
Functional Keywords | bromodomain, creb binding protein, structural genomics consortium, sgc, activator, disease mutation, host-virus interaction, metal-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase, zinc-finger |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q92793 |
Total number of polymer chains | 2 |
Total formula weight | 28632.90 |
Authors | Filippakopoulos, P.,Picaud, S.,Fedorov, O.,Karim, R.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Wickstroem, M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-07-23, release date: 2008-08-05, Last modification date: 2023-08-30) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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