3DWQ

Crystal structure of the A-subunit of the AB5 toxin from E. coli with Neu5Gc-2,3Gal-1,3GlcNAc

Summary for 3DWQ

Related3dwa 3dwp
DescriptorSubtilase cytotoxin, subunit B, 3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, BETA-D-GALACTOSE, ... (8 entities in total)
Functional Keywordstoxin
Biological sourceEscherichia coli
Total number of polymer chains5
Total molecular weight74674.37
Authors
Byres, E.,Paton, A.W.,Paton, J.C.,Lofling, J.C.,Smith, D.F.,Wilce, M.C.J.,Talbot, U.M.,Chong, D.C.,Yu, H.,Huang, S.,Chen, X.,Varki, N.M.,Varki, A.,Rossjohn, J.,Beddoe, T. (deposition date: 2008-07-22, release date: 2008-11-04, Last modification date: 2011-07-13)
Primary citation
Byres, E.,Paton, A.W.,Paton, J.C.,Lofling, J.C.,Smith, D.F.,Wilce, M.C.J.,Talbot, U.M.,Chong, D.C.,Yu, H.,Huang, S.,Chen, X.,Varki, N.M.,Varki, A.,Rossjohn, J.,Beddoe, T.
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin
Nature, 456:648-652, 2008
PubMed: 18971931 (PDB entries with the same primary citation)
DOI: 10.1038/nature07428
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26141.0%1.0%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload