3DWF
Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E
Summary for 3DWF
Entry DOI | 10.2210/pdb3dwf/pdb |
Descriptor | 11-beta-hydroxysteroid dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (5 entities in total) |
Functional Keywords | rossmann fold, short chain dehydrogenase reductase, sdr, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane |
Biological source | Cavia porcellus (Guinea pig) |
Cellular location | Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q6QLL4 |
Total number of polymer chains | 4 |
Total formula weight | 125635.44 |
Authors | Lawson, A.J.,Ride, J.P.,White, S.A.,Walker, E.A. (deposition date: 2008-07-22, release date: 2009-08-11, Last modification date: 2024-02-21) |
Primary citation | Lawson, A.J.,Walker, E.A.,White, S.A.,Dafforn, T.R.,Stewart, P.M.,Ride, J.P. Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system Protein Sci., 18:1552-1563, 2009 Cited by PubMed: 19507261DOI: 10.1002/pro.150 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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