3DWF

Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E

3DWF の概要

• エントリーDOI: 10.2210/pdb3dwf/pdb
• 分子名称: 11-beta-hydroxysteroid dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: rossmann fold, short chain dehydrogenase reductase, sdr, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane
• 由来する生物種: Cavia porcellus (Guinea pig)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q6QLL4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125635.44

構造登録者

Lawson, A.J.,Ride, J.P.,White, S.A.,Walker, E.A. (登録日: 2008-07-22, 公開日: 2009-08-11, 最終更新日: 2024-02-21)

• 主引用文献: Lawson, A.J.,Walker, E.A.,White, S.A.,Dafforn, T.R.,Stewart, P.M.,Ride, J.P.; Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system; Protein Sci., 18:1552-1563, 2009; PubMed: 19507261; DOI: 10.1002/pro.150

実験手法

X-RAY DIFFRACTION (2.2 Å)