3DW8

Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit

Summary for 3DW8

Entry DOI	10.2210/pdb3dw8/pdb
Related PRD ID	PRD_000212
Descriptor	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total)
Functional Keywords	holoenzyme, b55, pr55, wd repeat, hydrolase, iron, manganese, metal-binding, methylation, phosphoprotein, protein phosphatase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens More
Cellular location	Cytoplasm (By similarity): P30153 Cytoplasm: P67775
Total number of polymer chains	8
Total formula weight	306541.98
Authors	Xu, Y.,Chen, Y.,Zhang, P.,Jeffrey, P.D.,Shi, Y. (deposition date: 2008-07-21, release date: 2008-10-07, Last modification date: 2024-04-03)
Primary citation	Xu, Y.,Chen, Y.,Zhang, P.,Jeffrey, P.D.,Shi, Y. Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol.Cell, 31:873-885, 2008 Cited by PubMed: 18922469 DOI: 10.1016/j.molcel.2008.08.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation