3DW8
Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 582 | 64762.8 | 2 | UniProt (P30153) Pfam (PF02985) | Homo sapiens | PP2A, subunit A, PR65-alpha isoform, PP2A, subunit A, R1-alpha isoform, Medium tumor antigen-associated 61 kDa protein |
| 2 | B, E (B, E) | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | polymer | 447 | 51748.0 | 2 | UniProt (P63151) | Homo sapiens | PP2A, subunit B, B-alpha isoform, PP2A, subunit B, B55-alpha isoform, PP2A, subunit B, PR55-alpha isoform, PP2A, subunit B, R2-alpha isoform |
| 3 | C, F (C, F) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35636.2 | 2 | UniProt (P67775) Pfam (PF00149) | Homo sapiens | PP2A-alpha, Replication protein C, RP-C |
| 4 | G, H (G, H) | microcystin LR | polymer | 7 | 1014.2 | 2 | NOR (NOR00109) BIRD (PRD_000212) | Cyanobacteria | |
| 5 | I, J, K, L (C, F) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) |
Sequence modifications
A, D: 9 - 589 (UniProt: P30153)
B, E: 1 - 447 (UniProt: P63151)
| PDB | External Database | Details |
|---|---|---|
| Met 8 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 310 | Ile 310 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 306322.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 219.8 | |
| All* | Total formula weight | 306542.0 |
