3DUX

Understanding Thrombin Inhibition

3DUX の概要

• エントリーDOI: 10.2210/pdb3dux/pdb
• 関連するPDBエントリー: 2ZC9 2ZDA 2ZFP 2ZGX 2ZI2 2ZNK
• 関連するBIRD辞書のPRD_ID: PRD_000610
• 分子名称: Thrombin Light Chain, Thrombin Heavy Chain, Hirudin variant-1, ... (6 entities in total)
• 機能のキーワード: blood clotting, hydrolase inhibitor, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35735.12

構造登録者

Baum, B.,Heine, A.,Klebe, G. (登録日: 2008-07-18, 公開日: 2009-06-23, 最終更新日: 2023-11-15)

• 主引用文献: Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G.; Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin; J.Mol.Biol., 391:552-564, 2009; PubMed: 19520086; DOI: 10.1016/j.jmb.2009.06.016

実験手法

X-RAY DIFFRACTION (1.6 Å)