3DUE

CRYSTAL STRUCTURE OF A PUTATIVE PERIPLASMIC PROTEIN FROM DUF2874 FAMILY (BVU_2987) FROM BACTEROIDES VULGATUS ATCC 8482 AT 1.85 A RESOLUTION

Summary for 3DUE

• Entry DOI: 10.2210/pdb3due/pdb
• Descriptor: Putative periplasmic protein, CACODYLATE ION (3 entities in total)
• Functional Keywords: putative periplasmic protein, structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, unknown function
• Biological source: Bacteroides vulgatus ATCC 8482
• Total number of polymer chains: 1
• Total formula weight: 15026.19

Authors

Joint Center for Structural Genomics (JCSG) (deposition date: 2008-07-17, release date: 2008-08-05, Last modification date: 2024-10-09)

Primary citation

Das, D.,Finn, R.D.,Carlton, D.,Miller, M.D.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Bakolitsa, C.,Chen, C.,Chiu, H.J.,Chiu, M.,Clayton, T.,Deller, M.C.,Duan, L.,Ellrott, K.,Ernst, D.,Farr, C.L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, A.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Krishna, S.S.,Kumar, A.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Nopakun, A.,Okach, L.,Puckett, C.,Reyes, R.,Rife, C.L.,Sefcovic, N.,Tien, H.J.,Trame, C.B.,van den Bedem, H.,Weekes, D.,Wooten, T.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function.
Acta Crystallogr.,Sect.F, 66:1265-1273, 2010

PubMed Abstract: Proteins that contain the DUF2874 domain constitute a new Pfam family PF11396. Members of this family have predominantly been identified in microbes found in the human gut and oral cavity. The crystal structure of one member of this family, BVU2987 from Bacteroides vulgatus, has been determined, revealing a β-lactamase inhibitor protein-like structure with a tandem repeat of domains. Sequence analysis and structural comparisons reveal that BVU2987 and other DUF2874 proteins are related to β-lactamase inhibitor protein, PepSY and SmpA_OmlA proteins and hence are likely to function as inhibitory proteins.

PubMed: 20944221
DOI: 10.1107/S1744309109046788

Experimental method

X-RAY DIFFRACTION (1.85 Å)