3DS6
P38 complex with a phthalazine inhibitor
Summary for 3DS6
Entry DOI | 10.2210/pdb3ds6/pdb |
Descriptor | Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide (2 entities in total) |
Functional Keywords | kinase inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 4 |
Total formula weight | 169569.67 |
Authors | Herberich, B.,Syed, R.,Li, V.,Grosfeld, D. (deposition date: 2008-07-11, release date: 2008-10-07, Last modification date: 2024-04-03) |
Primary citation | Herberich, B.,Cao, G.Q.,Chakrabarti, P.P.,Falsey, J.R.,Pettus, L.,Rzasa, R.M.,Reed, A.B.,Reichelt, A.,Sham, K.,Thaman, M.,Wurz, R.P.,Xu, S.,Zhang, D.,Hsieh, F.,Lee, M.R.,Syed, R.,Li, V.,Grosfeld, D.,Plant, M.H.,Henkle, B.,Sherman, L.,Middleton, S.,Wong, L.M.,Tasker, A.S. Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51:6271-6279, 2008 Cited by PubMed: 18817365DOI: 10.1021/jm8005417 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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