3DS6

P38 complex with a phthalazine inhibitor

3DS6 の概要

• エントリーDOI: 10.2210/pdb3ds6/pdb
• 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide (2 entities in total)
• 機能のキーワード: kinase inhibitor complex, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 169569.67

構造登録者

Herberich, B.,Syed, R.,Li, V.,Grosfeld, D. (登録日: 2008-07-11, 公開日: 2008-10-07, 最終更新日: 2024-04-03)

• 主引用文献: Herberich, B.,Cao, G.Q.,Chakrabarti, P.P.,Falsey, J.R.,Pettus, L.,Rzasa, R.M.,Reed, A.B.,Reichelt, A.,Sham, K.,Thaman, M.,Wurz, R.P.,Xu, S.,Zhang, D.,Hsieh, F.,Lee, M.R.,Syed, R.,Li, V.,Grosfeld, D.,Plant, M.H.,Henkle, B.,Sherman, L.,Middleton, S.,Wong, L.M.,Tasker, A.S.; Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.; J.Med.Chem., 51:6271-6279, 2008; PubMed: 18817365; DOI: 10.1021/jm8005417

実験手法

X-RAY DIFFRACTION (2.9 Å)