3DRP

HIV reverse transcriptase in complex with inhibitor R8e

3DRP の概要

• エントリーDOI: 10.2210/pdb3drp/pdb
• 関連するPDBエントリー: 3DRR 3DRS
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile, ... (4 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, non-nucleoside inhibition, nucleotidyltrasferase, hydrolase, transferase
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117052.99

構造登録者

Yan, Y.,Prasad, S. (登録日: 2008-07-11, 公開日: 2008-10-14, 最終更新日: 2023-08-30)

• 主引用文献: Tucker, T.J.,Sisko, J.T.,Tynebor, R.M.,Williams, T.M.,Felock, P.J.,Flynn, J.A.,Lai, M.T.,Liang, Y.,McGaughey, G.,Liu, M.,Miller, M.,Moyer, G.,Munshi, V.,Perlow-Poehnelt, R.,Prasad, S.,Reid, J.C.,Sanchez, R.,Torrent, M.,Vacca, J.P.,Wan, B.L.,Yan, Y.; Discovery of 3-{5-[(6-Amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses.; J.Med.Chem., 51:6503-6511, 2008; PubMed: 18826204; DOI: 10.1021/jm800856c

実験手法

X-RAY DIFFRACTION (2.6 Å)