3DRP

HIV reverse transcriptase in complex with inhibitor R8e

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H	polymer	563	64895.3	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 (HIV-1)	p66 RT
2	B	p51 RT	polymer	443	51731.4	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 (HIV-1)
3	A	3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile	non-polymer		426.3	1	Chemie (R8E)
4		water	water		18.0	425	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Met -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Met -2	-	expression tag
Asn -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116626.7
Non-Polymers*	Number of molecules	1
	Total formula weight	426.3
All*	Total formula weight	117053.0

*Water molecules are not included.