3DQV

Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation

3DQV の概要

• エントリーDOI: 10.2210/pdb3dqv/pdb
• 分子名称: NEDD8, Cullin-5, Rbx1, ... (4 entities in total)
• 機能のキーワード: ubiquitin, nedd8, scf, cullin-ring ligase, cullin, nucleus, ubl conjugation pathway, host-virus interaction, receptor, ubl conjugation, acetylation, cytoplasm, dna damage, dna repair, metal-binding, zinc, zinc-finger, signaling protein, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q15843; Cytoplasm: P62877
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 134119.07

構造登録者

Duda, D.M.,Borg, L.A.,Scott, D.C.,Hunt, H.W.,Hammel, M.,Schulman, B.A. (登録日: 2008-07-09, 公開日: 2008-09-30, 最終更新日: 2011-07-13)

• 主引用文献: Duda, D.M.,Borg, L.A.,Scott, D.C.,Hunt, H.W.,Hammel, M.,Schulman, B.A.; Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.; Cell(Cambridge,Mass.), 134:995-1006, 2008; PubMed: 18805092; DOI: 10.1016/j.cell.2008.07.022

実験手法

X-RAY DIFFRACTION (3 Å)