3DNG

Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor

Summary for 3DNG

Entry DOI	10.2210/pdb3dng/pdb
Related	1UTT 1UTZ 1XUC 1XUD 1XUR 2OW9 2OZR
Descriptor	Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (5 entities in total)
Functional Keywords	hydrolase, selective inhibition, non-zinc chelating inhibitors, calcium, collagen degradation, extracellular matrix, glycoprotein, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasmic granule: P22894
Total number of polymer chains	2
Total formula weight	37580.43
Authors	Pochetti, G.,Montanari, R.,Mazza, F. (deposition date: 2008-07-02, release date: 2009-03-03, Last modification date: 2023-11-01)
Primary citation	Pochetti, G.,Montanari, R.,Gege, C.,Chevrier, C.,Taveras, A.G.,Mazza, F. Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8) J.Med.Chem., 52:1040-1049, 2009 Cited by PubMed: 19173605 DOI: 10.1021/jm801166j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation