3DNG

Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor

3DNG の概要

• エントリーDOI: 10.2210/pdb3dng/pdb
• 関連するPDBエントリー: 1UTT 1UTZ 1XUC 1XUD 1XUR 2OW9 2OZR
• 分子名称: Neutrophil collagenase, CALCIUM ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: hydrolase, selective inhibition, non-zinc chelating inhibitors, calcium, collagen degradation, extracellular matrix, glycoprotein, metal-binding, metalloprotease, polymorphism, protease, secreted, zinc, zymogen
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasmic granule: P22894
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37580.43

構造登録者

Pochetti, G.,Montanari, R.,Mazza, F. (登録日: 2008-07-02, 公開日: 2009-03-03, 最終更新日: 2023-11-01)

• 主引用文献: Pochetti, G.,Montanari, R.,Gege, C.,Chevrier, C.,Taveras, A.G.,Mazza, F.; Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S(1)' Subsite of Matrix Metalloproteinase 8 (MMP-8); J.Med.Chem., 52:1040-1049, 2009; PubMed: 19173605; DOI: 10.1021/jm801166j

実験手法

X-RAY DIFFRACTION (2 Å)